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PULMONARY DYSFUNCTION FROM LARGE AIRWAYS VERSUS SMALL AIRWAYS AMONG WATERPIPE SMOKERS.

Ghada Hamada1,3, Ghada Radwan1,3, Ebenezer Israel1,4, Mohamed Zakaria1,3, Maged El-Setouhy1,2, Mostafa Mohamed1,2  and Christopher Loffredo1,5 

Egyptian Smoking Prevention Research Institute (ESPRI)1, Ain Shams University Faculty of Medicine 2, Cairo University Faculty of Medicine 3, University of Maryland 4. Georgetown University 5

Abstract

A community survey was carried out to study the profile of lung dysfunction among waterpipe in comparison to cigarette smokers.

Methods:

A total of 358 cigarette smokers (10 or more cigarettes per day), 84 waterpipe smokers and 32 controls were tested for lung function using an expiratory flow/volume curve. The percent of predicted of FEV1 , FEF 25-75 and FVC values were calculated. The large airway ( FEV1 <80%) and small airway(FEF25-75 <65%) dysfunctions were categorized using the American Thoracic society guidelines.

Results:

Duration of smoking cigarette and waterpipe smoking was Mean (+S.D) 18.8+-11.5 and 13.0+-12.5 years respectively. Among cigarette smokers, 12.3% had both small and large airway dysfunction whereas 8.3% had both small and large airway dysfunction among waterpipe smokers , 14% of cigarette smokers had large airway dysfunction disease alone as compared to 8.3% for waterpipe smokers. Small airway dysfunction alone was present in 1.1% among cigarette smokers as compared to 4.8% for waterpipe smokers. As a validity check, persons with COPD were checked against large and small airway disease and 19 out of 22 COPD cases were found to have both large and small airway obstruction.

Conclusions:

 Isolated small airway dysfunction alone is uncommon for both cigarette and waterpipe smokers. Large airway alone or in combination with small airway dysfunction is the most common manifestation accounting for over a quarter of the cigarette smokers and one sixth of the waterpipe smokers. Cigarette smokers have significantly higher degree of small and large airway dysfunction.

 

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